GW501516 acts as an efficient PPARα activator in the mouse liver.
نویسندگان
چکیده
The peroxisome proliferator-activated receptor (PPAR) subtype specificity of GW501516, a well-known PPARδ-specific agonist, was studied by examining its effects on the expression of endogenous genes in primary hepatocytes and the liver of wild-type and PPARα-null mice. GW501516, like the PPARα-specific agonist Wy14,643, induced the expression of several PPAR target genes in a dose-dependent manner but this action was mostly absent in the cells and liver of PPARα-null mice. Results indicated that GW501516 acts as an efficient PPARα activator in the mouse liver.
منابع مشابه
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ورودعنوان ژورنال:
- Drug discoveries & therapeutics
دوره 5 4 شماره
صفحات -
تاریخ انتشار 2011